RNA expression preoperatively and postoperatively following total knee replacement: a pilot study in patients with and without chronic postsurgical pain.

Asokumar BuvanendranDan WangHyungsuk KimJeffrey S KroinRobert J McCarthy

Published in: Regional anesthesia and pain medicine (2019)

Despite a lack of clinical differences, patients who develop CPSP have upregulated pain pathways preoperatively; however, only the chemokine pathway remained differentially upregulated at 6 months postsurgery.

Keyphrases

chronic pain
pain management
neuropathic pain
poor prognosis
total knee arthroplasty
knee osteoarthritis
spinal cord
drug induced
anterior cruciate ligament