Prognostic and predictive value of PD-L2 DNA methylation and mRNA expression in melanoma.
Friederike HoffmannRomina ZarblDennis NiebelJudith SirokayAnne FröhlichChristian PoschTobias A W HolderriedPeter BrossartGonzalo SaavedraPia KusterSebastian StriethGerrit H GielenSandra S RingJörn DietrichTorsten PietschLukas FlatzGlen KristiansenJennifer LandsbergDimo DietrichPublished in: Clinical epigenetics (2020)
PD-L2 expression seems to be regulated via DNA promoter methylation. PD-L2 DNA methylation and mRNA expression may predict progression-free survival in melanoma patients receiving anti-PD-1 immunotherapy. Assessment of PD-L2 should be included in further clinical trials with anti-PD-1 antibodies.