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Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice.

Johan K E SpetzBritta LangenNils-Petter RudqvistToshima Z ParrisEmman ShubbarJohanna DalmoBo WängbergOla NilssonKhalil HelouEva Forssell-Aronsson
Published in: EJNMMI research (2019)
The present study indicates increased cellular stress responses in the tumors treated with a priming treatment schedule compared with those seen after conventional 177Lu-octreotate monotherapy, resulting in a more profound initiation of cell cycle arrest followed by apoptosis, as well as effects on PI3K/AKT-signaling and unfolded protein response.
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