Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice.
Johan K E SpetzBritta LangenNils-Petter RudqvistToshima Z ParrisEmman ShubbarJohanna DalmoBo WängbergOla NilssonKhalil HelouEva Forssell-AronssonPublished in: EJNMMI research (2019)
The present study indicates increased cellular stress responses in the tumors treated with a priming treatment schedule compared with those seen after conventional 177Lu-octreotate monotherapy, resulting in a more profound initiation of cell cycle arrest followed by apoptosis, as well as effects on PI3K/AKT-signaling and unfolded protein response.
Keyphrases
- cell cycle arrest
- pi k akt
- cell death
- signaling pathway
- cell proliferation
- combination therapy
- endoplasmic reticulum stress
- gene expression
- oxidative stress
- clinical trial
- type diabetes
- stem cells
- randomized controlled trial
- metabolic syndrome
- transcription factor
- open label
- autism spectrum disorder
- skeletal muscle
- binding protein
- replacement therapy
- mesenchymal stem cells
- heat shock
- smoking cessation