Interleukin-4 increases phagocytosis of necrotic cells by macrophages through scavenger receptor CD36.
Mingzhuang ChenGary TseWing Tak WongPublished in: Clinical and experimental pharmacology & physiology (2020)
Interleukin-4 can accelerate cell debris clearance by stimulating expression of CD36, which requires downstream STAT6 activation. Its beneficial effects on driving tissue repair and regeneration should be explored in future studies.