Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC).
Ian Z OngDennis L KolsonMatthew K SchindlerPublished in: Biomedicines (2023)
With a growing number of patients entering the recovery phase following infection with SARS-CoV-2, understanding the long-term neurological consequences of the disease is important to their care. The neurological complications of post-acute sequelae of SARS-CoV-2 infection (NC-PASC) represent a myriad of symptoms including headaches, brain fog, numbness/tingling, and other neurological symptoms that many people report long after their acute infection has resolved. Emerging reports are being published concerning COVID-19 and its chronic effects, yet limited knowledge of disease mechanisms has challenged therapeutic efforts. To address these issues, we review broadly the literature spanning 2020-2022 concerning the proposed mechanisms underlying NC-PASC, outline the long-term neurological sequelae associated with COVID-19, and discuss potential clinical interventions.
Keyphrases
- sars cov
- coronavirus disease
- liver failure
- respiratory syndrome coronavirus
- respiratory failure
- cerebral ischemia
- drug induced
- healthcare
- end stage renal disease
- aortic dissection
- systematic review
- ejection fraction
- newly diagnosed
- risk factors
- chronic kidney disease
- physical activity
- palliative care
- randomized controlled trial
- hepatitis b virus
- peritoneal dialysis
- quality improvement
- patient reported outcomes
- sleep quality
- white matter
- risk assessment
- intensive care unit
- acute respiratory distress syndrome
- brain injury
- blood brain barrier
- chronic pain
- electronic health record
- patient reported
- human health