Profiling the Urobiota in a Pediatric Population with Neurogenic Bladder Secondary to Spinal Dysraphism.
Flavio De MaioGiacomo GrottiFrancesco MarianiDaniele Antonio PizzutoGiulia SantarelliDelia Mercedes BiancoBrunella PosteraroMaurizio SanguinettiClaudia RendeliPublished in: International journal of molecular sciences (2023)
The human bladder has been long thought to be sterile until that, only in the last decade, advances in molecular biology have shown that the human urinary tract is populated with microorganisms. The relationship between the urobiota and the development of urinary tract disorders is now of great interest. Patients with spina bifida (SB) can be born with (or develop over time) neurological deficits due to damaged nerves that originate in the lower part of the spinal cord, including the neurogenic bladder. This condition represents a predisposing factor for urinary tract infections so that the most frequently used approach to treat patients with neurogenic bladder is based on clean intermittent catheterization (CIC). In this study, we analyzed the urobiota composition in a pediatric cohort of patients with SB compared to healthy controls, as well as the urobiota characteristics based on whether patients received CIC or not.
Keyphrases
- urinary tract
- spinal cord injury
- spinal cord
- endothelial cells
- urinary tract infection
- end stage renal disease
- induced pluripotent stem cells
- neuropathic pain
- pluripotent stem cells
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- traumatic brain injury
- patient reported outcomes
- low birth weight
- young adults
- brain injury