Exchange factor directly activated by cAMP-PKCε signalling mediates chronic morphine-induced expression of purine P2X3 receptor in rat dorsal root ganglia.

Wenying WangXiaqing MaLimin LuoMin HuangJing DongXiaoli ZhangWei JiangTao Xu

Published in: British journal of pharmacology (2018)

Chronic morphine exposure increased the expression of P2X3 receptor, and i.t. P2X3 receptor antagonists attenuated the loss of morphine's analgesic effect. Inhibiting Epac/PKCε signalling was shown to play a significant inhibitory role in chronic morphine-induced P2X3 receptor expression and attenuate morphine-induced tolerance.

Keyphrases

high glucose
diabetic rats
drug induced
poor prognosis
binding protein
oxidative stress
neuropathic pain
signaling pathway
anti inflammatory