Effects of Chinese medicinal herbs on expression of brain-derived Neurotrophic factor (BDNF) and its interaction with human breast cancer MDA-MB-231 cells and endothelial HUVECs.
Jen-Hwey ChiuFang-Pey ChenYi-Fang TsaiMan-Ting LinLing-Ming TsengYi-Ming ShyrPublished in: BMC complementary and alternative medicine (2017)
We conclude that BDNF plays an important role in the metastatic interaction between MDA-MB-231 and HUVEC cells. Some Chinese medicinal herbs are able to enhance the BDNF-related metastatic potential of the interaction between cancer cells and endothelial cells. These findings provide important information that should help with the development of integrated medical therapies for breast cancer patients.
Keyphrases
- vascular endothelial growth factor
- endothelial cells
- cell cycle arrest
- induced apoptosis
- high glucose
- small cell lung cancer
- squamous cell carcinoma
- cell death
- stress induced
- healthcare
- poor prognosis
- pi k akt
- breast cancer cells
- endoplasmic reticulum stress
- oxidative stress
- young adults
- signaling pathway
- long non coding rna