DNA Topoisomerase I differentially modulates R-loops across the human genome.

Stefano G ManzoStella R HartonoLionel A SanzJessica MarinelloSara De BiasiAndrea CossarizzaGiovanni CapranicoFrédéric Chedin

Published in: Genome biology (2018)

Our findings reveal new properties of Top1 in regulating R-loop homeostasis in a context-dependent manner and suggest a potential role for Top1 in modulating the replication process via R-loop formation.

Keyphrases

cell free
endothelial cells
genome wide
transcription factor
induced pluripotent stem cells
signaling pathway
pluripotent stem cells
single cell
dna methylation
gene expression
single molecule
nucleic acid