SPACE: Spatially variable gene clustering adjusting for cell type effect for improved spatial domain detection.

SPACE eliminates the need for prior knowledge about the number of gene clusters, known cell types, or the quantity of SVGs to identify clusters for downstream analysis.SPACE offers a method to effectively leverage SVGs for low-dimensional embedding within each cluster to improve the accuracy of spatial domain detection.The efficiency and utility of the SPACE algorithm have been validated across multiple datasets and simulations, demonstrating its effectiveness in producing meaningful and interpretable results.