Proteoglycan-4 regulates fibroblast to myofibroblast transition and expression of fibrotic genes in the synovium.

Marwa QadriGregory D JayLing X ZhangHolly RichendrferTannin A SchmidtKhaled A Elsaid

Published in: Arthritis research & therapy (2020)

PRG4 is an endogenous antifibrotic modulator in the joint and its effect on myofibroblast formation is partially mediated by CD44, but CD44 is not required to demonstrate an antifibrotic effect in vivo.

Keyphrases

pulmonary fibrosis
transforming growth factor
poor prognosis
nk cells
genome wide
binding protein
gene expression
dna methylation
wound healing
genome wide analysis