ZC3H13 suppresses colorectal cancer proliferation and invasion via inactivating Ras-ERK signaling.
Dehua ZhuJian-Ping ZhouJinbo ZhaoGuiyang JiangXiupeng ZhangYong ZhangMing DongPublished in: Journal of cellular physiology (2018)
ZC3H13 is a canonical CCCH zinc finger protein, which harbors a somatic frame-shift mutation in colorectal cancer (CRC). However, its expression and biological function were still uncertain. In the current study, we found that ZC3H13 was served as a tumor suppressor in CRC cells, which decreased the expression of Snail, Cyclin D1, and Cyclin E1, and increased the expression of Occludin and Zo-1 through inactivating Ras-ERK signaling pathway. Furthermore, reduction of ZC3H13 associated with advanced TNM stage (p = 0.02), positive regional lymph node metastasis ( p = 0.01). Taken together, the current study indicated that ZC3H13 may be an upstream regulator of Ras-ERK signaling pathway and suppressed invasion and proliferation of CRC.
Keyphrases
- signaling pathway
- pi k akt
- induced apoptosis
- cell cycle arrest
- poor prognosis
- epithelial mesenchymal transition
- lymph node metastasis
- binding protein
- squamous cell carcinoma
- cell cycle
- wild type
- gene expression
- copy number
- long non coding rna
- cell death
- dna methylation
- oxidative stress
- papillary thyroid
- small molecule