A French Real-World Evidence Study Evaluating the Efficacy, Safety, and Pharmacokinetic Parameters of rVIII-SingleChain in Patients with Hemophilia A Receiving Prophylaxis.

Benoit GuilletAbel HassounBénédicte WibautAnnie HarrocheChristine Biron-AndréaniYohan RepesseRoseline d'OironBrigitte TardyBrigitte Pan PeteschPierre ChamouniValérie GayMarc FouassierClaire PouplardCédric MartinHasan CatovicXavier Delavenne

Published in: Thrombosis and haemostasis (2023)

Patients who switched to rVIII-SingleChain prophylaxis demonstrated excellent bleed control and a reduction in infusion frequency. A population PK analysis revealed improved PK parameters compared with those reported in the clinical trial.

Keyphrases

clinical trial
single cell
randomized controlled trial
study protocol
open label
phase ii