ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease.
Qian MaQiuhua YangJiean XuXiaoyu ZhangDavid KimZhiping LiuQingen DaXiaoxiao MaoYaqi ZhouYongfeng CaiVidhi PareekHa Won KimGuangyu WuZheng DongWen-Liang SongLin GanChunxiang ZhangMei HongStephen J BenkovicNeal L WeintraubDavid J R FultonJohn M AsaraIssam Ben-SahraYuqing HuoPublished in: Circulation (2022)
These results reveal that de novo purine synthesis plays an important role in VSMC proliferation in arterial disease. These findings suggest that targeting ATIC is a promising therapeutic approach to combat arterial diseases.