Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.

Hang-Zhuo Li Shuguang QinJie TangTao WangWujing RenLingyun DiWenyan BoYixuan MaFangnan WuZujie XuWei SongMengxin CaiYue XiZhenjun Tian

Published in: Acta physiologica (Oxford, England) (2024)

Resistance exercise upregulates Fndc5 expression, activates AMPK-Sirt1 pathway, inhibits the activation of TGFβ1-Smad2/3 pathway, attenuates MF, and promotes cardiac function after MI.

Keyphrases

transforming growth factor
poor prognosis
left ventricular
epithelial mesenchymal transition
high intensity
signaling pathway
skeletal muscle
oxidative stress
physical activity
heart failure
ischemia reperfusion injury
binding protein
resistance training
atrial fibrillation
liver fibrosis