Single-cell RNA sequencing analysis of human kidney reveals the presence of ACE2 receptor: A potential pathway of COVID-19 infection.

Qiyu HeTsz N MokLiang YunChengbo HeJieruo LiJing-Hua Pan

Published in: Molecular genetics & genomic medicine (2020)

Our study provided the cellular evidence that SARS-Cov-2 invaded human kidney tissue via proximal convoluted tubule, proximal tubule, proximal straight tubule cells, and glomerular parietal cells by means of ACE2-related pathway and used their cellular protease TMPRSS2 for priming.

Keyphrases

single cell
induced apoptosis
endothelial cells
sars cov
cell cycle arrest
induced pluripotent stem cells
rna seq
endoplasmic reticulum stress
pluripotent stem cells
angiotensin converting enzyme
high throughput
cell death
signaling pathway
risk assessment
binding protein
respiratory syndrome coronavirus