Beta cell function and insulin sensitivity in obese youth with maturity onset diabetes of youth mutations vs type 2 diabetes in TODAY: Longitudinal observations and glycemic failure.
Silva A ArslanianLaure El GhormliMorey H HaymondChristine L ChanSteven D ChernausekRachelle G GandicaRose A Gubitosi-KlugLynne L LevitskyMaggie SiskaSteven M Willinull nullPublished in: Pediatric diabetes (2020)
In TODAY, β-cell function at randomization was worse in obese HNF-MODY youth compared with GCK-MODY youth, while insulin sensitivity was worse in non-MODY compared with the other two MODY groups. Over time, IS showed the greatest improvement in HNF-MODY youth. This raises the possibility that TODAY therapeutic modalities of insulin sensitization in these obese HNF-MODY youth may have played a beneficial role.