Nrf2 Inhibits GAPDH/Siah1 Axis to Reduce Inflammatory Reactions and Proliferation of Microglia After Simulating Spinal Cord Injury.

Chunhe ShaFeng PanZhiqing WangGuohui LiuHua WangTianwei HuangKai Huang

Published in: Current molecular medicine (2024)

Up-regulating Nrf2 expression can reverse the inflammatory reaction of microglia after LPS stimulation and enhance their activity by inhibiting the GAPDH/Siah1 axis.

Keyphrases

oxidative stress
inflammatory response
spinal cord injury
neuropathic pain
signaling pathway
poor prognosis
spinal cord
binding protein