Polystyrene Microplastics Exacerbate Candida albicans Infection Ability In Vitro and In Vivo.
Angela MaioneMariangela NorciaMarica SinocaMarilena GaldieroValeria MaselliAntonia FeolaRosa CarotenutoPaola CuomoRosanna CapparelliMarco GuidaEmilia GaldieroPublished in: International journal of molecular sciences (2023)
Plastic pollution is an important environmental problem, and microplastics have been shown to have harmful effects on human and animal health, affecting immune and metabolic physiological functions. Further, microplastics can interfere with commensal microorganisms and exert deleterious effects on exposure to pathogens. Here, we compared the effects of 1 µm diameter polystyrene microplastic (PSMPs) on Candida albicans infection in both in vitro and in vivo models by using HT29 cells and Galleria mellonella larvae, respectively. The results demonstrated that PSMPs could promote Candida infection in HT29 cells and larvae of G. mellonella , which show immune responses similar to vertebrates. In this study, we provide new experimental evidence for the risk to human health posed by PSMPs in conjunction with Candida infections.
Keyphrases
- candida albicans
- human health
- risk assessment
- biofilm formation
- induced apoptosis
- climate change
- cell cycle arrest
- immune response
- heavy metals
- endothelial cells
- healthcare
- endoplasmic reticulum stress
- public health
- mental health
- escherichia coli
- oxidative stress
- toll like receptor
- aedes aegypti
- social media
- drosophila melanogaster
- gram negative
- dendritic cells
- particulate matter
- optic nerve
- drinking water
- antimicrobial resistance
- pluripotent stem cells
- multidrug resistant
- cystic fibrosis
- health promotion