A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases.

Eva LukasRada R VeenemanDirk Ja Smitnull nullJentien M VermeulenGita A Pathak Renato PolimantiKarin Jh VerweijJorien L Treur

Published in: medRxiv : the preprint server for health sciences (2024)

In addition to shared genetic liability between PTSD and CVD, we present strong evidence for causal effects of PTSD on CVD. Crucially, we implicate specific lifestyle and biological mediators (insomnia, substance use, inflammation) which has important implications for interventions to prevent CVD in PTSD patients.

Keyphrases

posttraumatic stress disorder
cardiovascular disease
end stage renal disease
physical activity
ejection fraction
genome wide
oxidative stress
social support
peritoneal dialysis
prognostic factors
copy number
weight loss
coronary artery disease
dna methylation
cardiovascular events
patient reported