Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study.
Fahmi ShaherShuqiu WangHong-Bin QiuYu HuYu ZhangWeiqun WangHisham Al-WardMahfoudh A M AbdulghaniSalem BaldiShaobo ZhouPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)
The results indicated that GLS treatment alleviates diabetic cardiomyopathy by reducing hyperglycemia, oxidative stress, inflammation, apoptosis and further attenuating the fibrosis and myocardial dysfunction induced by STZ through stimulation of the PI3K/Akt/mTOR signaling pathway.