Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A).

Songye LiZhengxin CaiWenjie ZhangDaniel HoldenShu-Fei LinSjoerd J FinnemaAnupama ShiraliJim RopchanStephane CarreJoel MercierRichard E CarsonNabeel NabulsiYiyun Huang

Published in: European journal of nuclear medicine and molecular imaging (2019)

We have accomplished the first synthesis of the novel SV2A radiotracer [18F]UCB-J. [18F]UCB-J is demonstrated to be an excellent imaging agent and may prove to be useful for imaging and quantification of SV2A expression, and synaptic density, in humans.

Keyphrases

pet imaging
high resolution
poor prognosis
computed tomography
mass spectrometry
photodynamic therapy