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The influence of brain metastases on the central nervous system effects of methylnaltrexone: a post hoc analysis of 3 randomized, double-blind studies.

Darren R BrennerNeal E SlatkinNancy StamblerRobert J IsraelPaul H Coluzzi
Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2021)
Focal disruptions of the BBB caused by brain metastases did not appear to alter central nervous system penetrance of MNTX.
Keyphrases
  • brain metastases
  • double blind
  • placebo controlled
  • small cell lung cancer
  • phase iii
  • clinical trial
  • cerebrospinal fluid
  • phase ii
  • blood brain barrier
  • open label
  • study protocol
  • case control
  • randomized controlled trial