The identification and verification of hub genes associated with pulmonary arterial hypertension using weighted gene co-expression network analysis.
Weibin WuAi ChenSiming LinQiuran WangGuili LianLi LuoLiang-Di XiePublished in: BMC pulmonary medicine (2022)
PNISR and HNRNPH1 were potential biomarkers to diagnosis PAH. In summary, the identified DEGs, modules, pathways, and hub genes provide clues and shed light on the potential molecular mechanisms of PAH.
Keyphrases
- network analysis
- pulmonary arterial hypertension
- bioinformatics analysis
- genome wide identification
- genome wide
- pulmonary artery
- pulmonary hypertension
- poor prognosis
- polycyclic aromatic hydrocarbons
- copy number
- genome wide analysis
- transcription factor
- binding protein
- dna methylation
- human health
- long non coding rna
- risk assessment
- magnetic resonance imaging
- coronary artery