Low-level laser and adipose-derived stem cells altered remodelling genes expression and improved collagen reorganization during tendon repair.

Letícia D LuckeFernanda O BortolazzoViviane TheodoroLucas FujiiAndré Luis BombeiroMaíra FelonatoRodrigo A DaliaGiane D CarneiroLuciana Politti CartarozziCristina Pontes VicenteAlexandre L R OliveiraFernanda A S MendonçaMarcelo A M EsquisattoEdson R PimentelAndrea Aparecida de Aro

Published in: Cell proliferation (2019)

Transplanted ASCs migrated to the transected region, and all treatments altered the remodelling genes expression. The LLL was the most effective in the collagen reorganization, followed by its combination with ASCs. Further investigations are needed to elucidate the molecular mechanisms involved in the LLL and ASCs combination during initial phases of tendon repair.

Keyphrases

poor prognosis
genome wide
wound healing
binding protein
bioinformatics analysis
anterior cruciate ligament reconstruction
genome wide identification
rotator cuff
long non coding rna
dna methylation
gene expression
tissue engineering
mass spectrometry
transcription factor
high speed