High Mobility Group A 1 Expression as a Poor Prognostic Marker Associated with Tumor Invasiveness in Gastric Cancer.
Hung-Pin ChangJen-Tang SunChiao-Yin ChengYao-Jen LiangYen-Lin ChenPublished in: Life (Basel, Switzerland) (2022)
The prognosis of advanced gastric cancer remains poor. Overexpression of high mobility group A 1 (HMGA1) in breast cancer and neuroblastoma indicates a poor prognosis. However, the relationship between HMGA1 expression and gastric cancer development remains unclear. Treatment strategies can be developed by identifying potential markers associated with gastric cancer. We used a constructed tissue array and performed hematoxylin and eosin and immunohistochemical staining. We quantified the staining results and performed statistical analysis to evaluate the relationship between HMGA1 expression and prognosis. HMGA1 expression was related to the expression of Ki-67, caspase3, CD31, N-cadherin, fibronectin, pAkt, and pErk. In the Kaplan-Meier graph, higher HMGA1 expression levels were associated with a relatively poor survival rate ( p = 0.04). High expression of HMGA1 leads to a low survival rate, which is associated with HMGA1, proliferation, apoptosis, angiogenesis, epithelial-mesenchymal transition, and tyrosine kinase.
Keyphrases
- poor prognosis
- long non coding rna
- tyrosine kinase
- epithelial mesenchymal transition
- binding protein
- cell death
- endoplasmic reticulum stress
- endothelial cells
- signaling pathway
- mass spectrometry
- neoadjuvant chemotherapy
- high throughput
- risk assessment
- single cell
- epidermal growth factor receptor
- induced apoptosis
- nk cells
- free survival
- vascular endothelial growth factor
- flow cytometry
- drug induced
- cell migration