Cytotoxicity and Induction of G1 Phase Cell Cycle Arrest in human acute promyelocytic leukemia HL60 cells by indole alkaloids isolated from Dialium corbisieri seeds.
Dradre Atakuru PaulinTakuya KosekiNarandulam UsukhbayarKen-Ichi KimuraYoshihito ShionoPublished in: Bioscience, biotechnology, and biochemistry (2023)
The phytochemical investigation of Dialium corbisieri seeds led to the isolation of five monoterpenoid indole alkaloids along with a phytoserotonin, 1-6 and among the known compounds, the spectroscopic data of (5S)-methoxy-akuammiline (1) was reported for the first time. The structures were elucidated based on NMR spectroscopic techniques such as UV, IR, HRESITOFMS, and ECD spectrum calculations. The isolated compounds were evaluated for their cytotoxicity and cell progression in the human acute promyelocytic leukemia HL60 cell line.
Keyphrases
- cell cycle arrest
- endothelial cells
- cell death
- liver failure
- pi k akt
- molecular docking
- acute myeloid leukemia
- bone marrow
- respiratory failure
- induced pluripotent stem cells
- high resolution
- pluripotent stem cells
- electronic health record
- drug induced
- stem cells
- single cell
- aortic dissection
- cell therapy
- cell proliferation
- signaling pathway
- big data
- mass spectrometry
- mesenchymal stem cells
- machine learning
- deep learning
- data analysis