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Twenty years of FISH-based translocation analysis for retrospective ionizing radiation biodosimetry.

Eric GrégoireLaurence RoyValérie BuardMartine DelbosValérie DurandCécile Martin-BodiotPascale VoisinIrène Sorokine-DurmAurélie VaurijouxPhilippe VoisinCéline BaldeyronJoan-Francesc Barquinero
Published in: International journal of radiation biology (2018)
This technique is appropriate for corroborating a former IR exposure of individuals. When the radiation dose is greater than 1 Gy, the translocations in complex exchanges must be considered. Another relevant point is the use of an appropriate background yield of translocations. The dose assessment, however, also depends on exposure to various genotoxic agents besides IR. If no evidence about the existence of radiation exposure is available, dose assessment is not useful. For this reason, report only the translocation frequency and its comparison with the background yield by age class is preferable.
Keyphrases
  • cross sectional