Expression of KLRG1 and CD127 defines distinct CD8+ subsets that differentially impact patient outcome in follicular lymphoma.

Hongyan WuXinyi TangHyo Jin KimShahrzad JalaliJoshua C PritchettJose C VillasboasAnne J NovakZhi-Zhang YangStephen M Ansell

Published in: Journal for immunotherapy of cancer (2022)

Taken together, these results reveal not only a biological and prognostic role for KLRG1/CD127-defined CD8+ subsets in FL but also a potential role for PI3K inhibitors to manipulate the differentiation of CD8+ T cells, thereby promoting a more effective antitumor immune response.

Keyphrases

immune response
nk cells
poor prognosis
peripheral blood
case report
genome wide
dna methylation
dendritic cells
long non coding rna
toll like receptor
inflammatory response