PD-L1, B7-H3, and PD-1 expression in immunocompetent vs. immunosuppressed patients with cutaneous squamous cell carcinoma.

Vinod VarkiOlga B IoffeSoren M BentzenJon HeathAshley CelliniJosephine FelicianoDan P Zandberg

Published in: Cancer immunology, immunotherapy : CII (2018)

cSCC showed expression of PD-L1 on tumor in 26% of cases, and high tumor B7-H3 expression (85%) and PD-1 expression on CD8 TILs (80%). Tumor B7-H3 expression was significantly higher in immunocompetent vs. immunosuppressed patients, largely driven by very low expression in HIV+ patients.

Keyphrases

hiv testing
poor prognosis
squamous cell carcinoma
end stage renal disease
newly diagnosed
long non coding rna
peritoneal dialysis
radiation therapy
hepatitis c virus
hiv infected
south africa