EML4-ALK fusion protein in Lung cancer cells enhances venous thrombogenicity through the pERK1/2-AP-1-tissue factor axis.

Yanping SuJiawen YiYuan ZhangDong LengXiaoxi HuangXinyu ShiYuhui Zhang

Published in: Journal of thrombosis and thrombolysis (2023)

EML4-ALK fusion protein may enhance venous thrombogenicity by regulating coagulation factor TF expression. There was potential involvement of the pERK1/2-AP-1 pathway in this process.

Keyphrases

endoplasmic reticulum stress
transcription factor
advanced non small cell lung cancer
poor prognosis
endoplasmic reticulum
binding protein
epidermal growth factor receptor
long non coding rna
tyrosine kinase