HDL protects against myocardial ischemia reperfusion injury via miR-34b and miR-337 expression which requires STAT3.
Sarah PedrettiMarie-Claude Brulhart-MeynetFabrizio MontecuccoSandrine LecourRichard W JamesMiguel A FriasPublished in: PloS one (2019)
Our study, performed both in vivo and in vitro, delineates a novel cardioprotective signalling pathway activated by HDL, involving STAT3-mediated decrease of miR-34b and miR-337 expression.