Immune memory shapes human polyclonal antibody responses to H2N2 vaccination.
Yuhe Renee YangJulianna HanHailee R PerrettSara T RicheyAbigail M JacksonAlesandra J RodriguezRebecca A GillespieSarah O'ConnellJulie E RaabLauren Y CominskyAnkita ChopdeMasaru KanekiyoKatherine V HouserGrace L ChenAdrian B McDermottSarah F AndrewsAndrew B WardPublished in: bioRxiv : the preprint server for biology (2023)
Serum Abs after first H2-F vaccination in H2-exposed donors bound variable HA head epitopesSerum Abs after first H2-F vaccination in H2-naïve donors bound conserved HA head and stem epitopesRBS-targeting VH1-69 cross-reactive antibodies were induced in H2-naïve individualsThe medial junction is a previously uncharacterized conserved epitope on the HA head.