Prognostic relevance of programmed cell death-ligand 1 expression and CD8+ TILs in rectal cancer patients before and after neoadjuvant chemoradiotherapy.

Tsung-Wei ChenKevin Chih-Yang HuangShu-Fen ChiangWilliam Tzu-Liang ChenTao-Wei KeK S Clifford Chao

Published in: Journal of cancer research and clinical oncology (2019)

The present results provide evidence that tumor PD-L1 expression and recruitment of CD8+ TILs within the tumor microenvironment were increased by neoCRT treatment. Tumor PD-L1 and CD8+ TILs are prognostic biomarkers for the survival of LARC patients treated with neoCRT.

Keyphrases

rectal cancer
locally advanced
nk cells
poor prognosis
lymph node
squamous cell carcinoma
radiation therapy
binding protein
combination therapy