Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages.
Elisenda Alsina-SanchisRonja MülfarthIris MollSarah BöhnLena WiedmannLorea Jordana-UrrizaTara ZiegelbauerEleni ZimmerJacqueline TaylorFrancesca De Angelis RigottiAdrian StögbauerBenedetto Daniele GiaimoAdelheid CerwenkaTilman BorggrefeAndreas FischerJuan Rodriguez-VitaPublished in: Cancer research (2022)
Endothelial Notch signaling favors immunosuppression by increasing CXCL2 secretion to stimulate CD44 expression in macrophages, facilitating their education by tumor cells.