Correlation of Transcriptomics and FDG-PET SUVmax Indicates Reciprocal Expression of Stemness-Related Transcription Factor and Neuropeptide Signaling Pathways in Glucose Metabolism of Ewing Sarcoma.
Carolin PrexlerMarie Sophie KnapeJanina Erlewein-SchweizerWolfgang RollKatja SpechtKlaus WoertlerWilko WeichertIrene von LuettichauClaudia RossigJulia HauerGuenther H S RichterWolfgang WeberStefan E G BurdachPublished in: Cancers (2022)
Our large-scale analysis examined comprehensively the correlations between transcriptomics and tumor glucose utilization. Based on our findings, we hypothesize that stemness may be associated with increased glucose uptake, whereas neuroectodermal differentiation may anticorrelate with glucose uptake.