Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality.
Tiffany ThomasFrancesca CendaliXiaoyun FuFabia GamboniEvan J MorrisonJonathan BeirneTravis NemkovMarianna H AntonelouAnastasios KriebardisIan WelsbyAriel HayKarolina H Dziewulska-CronkMichael P BuschSteven KleinmanPaul W BuehlerSteven L SpitalnikJames C ZimringAngelo D'AlessandroPublished in: Transfusion (2021)
Fatty acid desaturases are present and active in mature RBCs. Their activity is sensitive to oxidant stress, storage duration, and alterations of the pyruvate/lactate ratio.