Evidence for an early innate immune response in the motor cortex of ALS.

Javier H JaraBarış GençMacdonell J StanfordPeter PytelRaymond P RoosSandra WeintraubM Marsel MesulamEileen H BigioRichard J MillerP Hande Özdinler

Published in: Journal of neuroinflammation (2017)

Our findings reveal that the intricate cellular interplay between immune cells and upper motor neurons observed in the motor cortex of ALS mice is indeed recapitulated in ALS patients. We generated and characterized a novel model system, to study the cellular and molecular basis of this close cellular interaction and how that relates to motor neuron vulnerability and progressive degeneration in ALS.

Keyphrases

amyotrophic lateral sclerosis
innate immune
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
multiple sclerosis
peritoneal dialysis
climate change
prognostic factors
spinal cord
type diabetes
genome wide
single cell
skeletal muscle
insulin resistance