ATP-evoked intracellular Ca2+ transients shape the ionic permeability of human microglia from epileptic temporal cortex.

Nicole Piera PalombaKatiuscia MartinelloGermana CocozzaSara CasciatoAddolorata MasciaGiancarlo Di GennaroRoberta MoraceVincenzo EspositoHeike WulffCristina LimatolaSergio Fucile

Published in: Journal of neuroinflammation (2021)

Our study confirms a functional role for KCa3.1 channels in human microglia, linking ATP-evoked Ca2+ transients to changes in membrane conductance, with an inflammation-dependent mechanism, and suggests that during brain inflammation the KCa3.1-mediated microglial response to purinergic signaling may be reduced.

Keyphrases

endothelial cells
inflammatory response
oxidative stress
neuropathic pain
induced pluripotent stem cells
pluripotent stem cells
white matter
multiple sclerosis
reactive oxygen species
resting state
protein kinase
blood brain barrier
subarachnoid hemorrhage
solid state