The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian-randomization analyses.
Humaira RasheedJie ZhengJessica M B ReesEleanor C M SandersonLaurent ThomasTom G RichardsonSi FangOle-Jørgen BekkevoldEndre Bakken StovnerMaiken Elvestad GabrielsenAnne Heidi SkogholtSolfrid RomundstadBen Michael BrumptonStein HallanCristen WillerStephen BurgessKristian HveemGeorge Davey SmithTom R GauntBjørn Olav ÅsvoldPublished in: International journal of epidemiology (2021)
Our MR estimates suggest that serum lipid and apolipoprotein levels do not cause substantial changes in kidney function. A possible weak effect of higher atherogenic lipids on increased eGFR and UACR warrants further investigation. Processes leading to higher UACR may lead to more atherogenic lipid levels.