Depletion of hepatic stellate cells inhibits hepatic steatosis in mice.

Akihiro KawaharaKeishi KannoSayaka YonezawaYuichiro OtaniTomoki KobayashiSusumu TazumaMasanori Ito

Published in: Journal of gastroenterology and hepatology (2022)

In addition to the improvement in hepatic fibrogenesis, depletion of HSCs had a favorable effect on hepatic lipid metabolism in a mouse NASH model, suggesting that HSCs are potentially efficient targets for the treatment of NASH.

Keyphrases

induced apoptosis
cell cycle arrest
high fat diet induced
endoplasmic reticulum stress
fatty acid
signaling pathway
adipose tissue
cell proliferation