A novel orthotopic mouse model replicates human lung cancer cachexia.

Wouter R P H van de WorpJan TheysAlba Sanz GonzálezBrent van der HeydenFrank VerhaegenDuncan HauserFlorian CaimentHubertus J M SmeetsAnnemie M W J ScholsArdy van HelvoortRamon C J Langen

Published in: Journal of cachexia, sarcopenia and muscle (2023)

We developed an orthotopic model of lung cancer cachexia in immune competent mice. Because this model simulates key aspects specific to cachexia in lung cancer patients, it is highly suitable to further investigate the underlying mechanisms of lung cancer cachexia and to test the efficacy of novel intervention strategies.

Keyphrases

mouse model
endothelial cells
randomized controlled trial
type diabetes
high fat diet induced
induced pluripotent stem cells