STING and cGAS gene expressions were downregulated among HIV-1-infected persons after antiretroviral therapy.
Lorena Leticia Peixoto de LimaAllysson Quintino Tenório de OliveiraTuane Carolina Ferreira MouraEdnelza da Silva Graça AmorasSandra Souza LimaAndrea Nazaré Monteiro Rangel da SilvaMaria Alice Freitas QueirozIzaura Maria Vieira Cayres-VallinotoRicardo IshakAntonio Carlos Rosário VallinotoPublished in: Virology journal (2021)
ART provided immune recovery and viral suppression to the studied group and indirectly downregulated the STING and cGAS genes. In contrast, ART did not influence IFN-α. The expression of STING and cGAS was not correlated with the plasma level of IFN-α, which suggests that there is another pathway regulating this cytokine in addition to the STING-cGAS pathway.
Keyphrases
- hiv infected
- antiretroviral therapy
- human immunodeficiency virus
- hiv infected patients
- hiv positive
- hiv aids
- genome wide
- dendritic cells
- immune response
- poor prognosis
- magnetic resonance
- genome wide identification
- copy number
- magnetic resonance imaging
- computed tomography
- contrast enhanced
- hepatitis c virus
- men who have sex with men