Kininogen-1 as a protein biomarker for schizophrenia through mass spectrometry and genetic association analyses.
Mingjia YangNa ZhouHuiping ZhangGuojun KangBonan CaoQi KangRixin LiXiaojing ZhuWen-Wang RaoQiong YuPublished in: PeerJ (2019)
The present study demonstrated that SCZ patients had decreased expression of Kininogen-1 and genetic variants in Kininogen-1 coding gene CST9 were significantly associated with SCZ. The findings from both protein and genetic association studies suggest that Kininogen-1 could be a biomarker of SCZ.
Keyphrases
- mass spectrometry
- genome wide
- end stage renal disease
- copy number
- ejection fraction
- chronic kidney disease
- binding protein
- newly diagnosed
- poor prognosis
- bipolar disorder
- protein protein
- peritoneal dialysis
- liquid chromatography
- prognostic factors
- high resolution
- high performance liquid chromatography
- patient reported outcomes
- genome wide identification