High-fat diet intake ameliorates the expression of hedgehog signaling pathway in adult rat liver.
Muhammad Babar KhawarNadeem SheikhMuhammad Babar KhawarMuddasir Hassan AbbasiMaryam MukhtarPublished in: Molecular biology reports (2022)
Excess fat deposits in liver due to chronic consumption of high-fat diet results in anomalous architecture and functioning. High-fat diet induced significant variations in Hh pathway genes expression; especially Shh, Ihh, Hhip, Ptch1, Smo, Gli1, Gli2, and Gli3 were upregulated. Infiltration of inflammatory cells ( ), widened sinusoidal spaces (▲), cellular necrosis, and micro vesicular steatotic hepatocytes (*) were shown in the liver. Significant collagen deposition in both HFD groups i.e. D-1 and D-2 confirmed liver fibrosis. Excessive intake of dietary fats impaired normal liver functioning and liver inflammation triggered Hh signaling in adult rats.
Keyphrases
- high fat diet
- insulin resistance
- adipose tissue
- signaling pathway
- oxidative stress
- high fat diet induced
- poor prognosis
- liver fibrosis
- induced apoptosis
- weight gain
- epithelial mesenchymal transition
- metabolic syndrome
- genome wide
- liver injury
- mouse model
- long non coding rna
- drug induced
- cell proliferation
- childhood cancer
- genome wide analysis