Resensitizing tigecycline- and colistin-resistant Escherichia coli using an engineered conjugative CRISPR/Cas9 system.

Haijie ZhangBo ChenZeyu WangKai PengYuan Liu Zhiqiang Wang

Published in: Microbiology spectrum (2024)

after the resensitization system was administered. This study opens up new pathways for the development of CRISPR-based tools for selective bacterial pathogen elimination and precise microbiome composition change.

Keyphrases

crispr cas
escherichia coli
genome editing
klebsiella pneumoniae
acinetobacter baumannii
multidrug resistant
pseudomonas aeruginosa
drug resistant
gram negative
biofilm formation
gene expression