The inhibitory effect of tocilizumab on systemic bone loss and tendon inflammation in a juvenile Collagen-Induced arthritis rat model.

Freideriki Poutoglidou Chryssa PourzitakiMaria Eleni ManthouEfthimios SamoladasAthanasios SaitisFoteini MalliouDimitrios Kouvelas

Published in: Connective tissue research (2022)

The results of the present study provide evidence that tocilizumab reduces inflammation-related bone loss and suppresses tendon inflammation in a juvenile CIA rat model. These findings offer perspectives for the management of osteoporosis and enthesitis in JIA.

Keyphrases

bone loss
juvenile idiopathic arthritis
oxidative stress
rheumatoid arthritis
diabetic rats
rheumatoid arthritis patients
signaling pathway
drug induced
postmenopausal women
rotator cuff