Genetic polymorphism of WNT9A is functionally associated with thumb osteoarthritis in the Chinese population.

Jian DaiHaitao JiangZhang ChengYao LiZhaoqi YangChuan ChengXiaoming Tang

Published in: Advances in rheumatology (London, England) (2024)

Allele G of rs11588850 was associated with the increased risk of TOA possibly via up-regulation of WNT9A expression. Further functional analysis into the regulatory role of rs11588850 in WNT9A expression can shed new light on the genetic architecture of TOA.

Keyphrases

poor prognosis
cell proliferation
stem cells
genome wide
binding protein
copy number
long non coding rna
dna methylation
gene expression