3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma.
Bianyun CaiLeizhen HuangJingcheng WangDan SunCe ZhuYong HuangShujun LiZhijun GuoLimin LiuLeizhen HuangYubao LiLi ZhangPublished in: Bioconjugate chemistry (2021)
Osteosarcoma is a challenging bone disease which is commonly associated with critically sized bone defects and cancer recurrence. Here, we designed and developed a multifunctional, hierarchical structured bone scaffold which can meet the demanding requirements for osteosarcoma management. The 3D printed Ti6Al4V scaffold with hydrothermally induced TiO2/TiP coating can offer a unique photothermal conversion property for in vitro bone cancer ablation. The scaffold is also infused with drug-laden gelatin/hydroxyapatite nanocomposite, which provides the ideal porous structure for cell adhesion/bone ingrowth and promotes bone regeneration. The scaffold has been thoroughly characterized by SEM/EDX, TEM, XPS, XRD, TGA, and UV-vis, and its in vitro bone cancer ablation efficiency has been validated using MG-63 cells. The hybrid scaffold showed excellent biocompatibility, and its osteointegration function has been demonstrated using an animal model.
Keyphrases
- bone regeneration
- tissue engineering
- bone mineral density
- papillary thyroid
- bone loss
- soft tissue
- drug delivery
- postmenopausal women
- cell adhesion
- cancer therapy
- body composition
- squamous cell carcinoma
- emergency department
- cell death
- cell proliferation
- high resolution
- high glucose
- quantum dots
- young adults
- childhood cancer
- pi k akt
- endoplasmic reticulum stress
- radiofrequency ablation
- lactic acid