Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells.
I-Chun LaiGi-Ming LaiJyh-Ming ChowHsin-Lun LeeChuan-Feng YehChi-Han LiJiann-Long YanShuang-En ChuangJacqueline Whang-PengKuan-Jen BaiChih-Jung YaoPublished in: Chinese medicine (2017)
The active fraction HS7 from n-hexane extract of T. camphoratus exerts multi-targeting activity on the suppression of AKT-mTOR, ERK and STAT3 pathways and induction of p15, p21 and p27 in EGFR wild-type NSCLC cells. This multi-targeting activity of HS7 suggests its potential as an alternative medicine for the treatment of EGFR TKIs resistant NSCLC.
Keyphrases
- cell proliferation
- small cell lung cancer
- signaling pathway
- cell cycle
- wild type
- pi k akt
- induced apoptosis
- epidermal growth factor receptor
- cell cycle arrest
- advanced non small cell lung cancer
- tyrosine kinase
- endothelial cells
- cancer therapy
- brain metastases
- induced pluripotent stem cells
- cell death
- endoplasmic reticulum stress
- combination therapy
- pluripotent stem cells
- anti inflammatory